Folic Acid and Fertility

The Essential Role of Folic Acid in Fertility and Reproductive Health

Folic acid, a synthetic form of folate, is a vital B-vitamin found naturally in various foods and available as a dietary supplement. It plays a crucial role in our diet, especially for those focusing on reproductive health. Folate, the natural form of this vitamin, is abundant in leafy greens, fruits, and nuts, while folic acid is often found in fortified foods.

                                                                                                             – Dr. G. A. Ramaraju DNB PhD, Consultant Krishna IVF Clinic

Biological Role of Folic Acid

Folic acid is integral to DNA synthesis, repair, and methylation. These processes are essential for cell division and growth, making folic acid a key nutrient for reproductive health. Its involvement in genetic material formation underpins its importance in both conception and pregnancy.

Folic Acid and Female Fertility

Research links folic acid intake to a decreased risk of ovulatory infertility. Women undergoing assisted reproductive technologies (ART) often find improved outcomes with adequate folic acid levels. This correlation emphasizes folic acid’s role in supporting healthy ovulation and embryo development.

Folic Acid and Male Fertility

In men, folic acid’s benefits extend to sperm health. Studies show that sufficient folic acid levels are associated with higher sperm counts and better sperm quality. This highlights its importance in male fertility and the overall process of conception.

Folic Acid and Pregnancy

One of folic acid’s most critical roles is in preventing neural tube defects and other congenital anomalies in the fetus. This prevention aspect underlines the necessity of adequate folic acid intake during the early stages of pregnancy.

Sources of Folic Acid

Folic acid is abundant in leafy green vegetables, fruits, nuts, and fortified foods. Given its importance, many diets include these foods to ensure sufficient intake. Supplements are also a common and effective way to meet daily folic acid requirements.

Recommended Intake and Supplementation

The recommended daily intake of folic acid varies, but it’s particularly crucial for individuals planning to conceive. Healthcare professionals often advise a specific dosage based on individual health needs.


Folic acid’s role in fertility and reproductive health cannot be overstated. It’s a key nutrient that supports both male and female fertility and is essential for the healthy development of the fetus.

1. Gaskins, Audrey J., Myriam C. Afeiche, Daria L. Wright, et al. “Dietary Folate and Reproductive Success Among Women Undergoing Assisted Reproduction.” Obstetrics & Gynecology 124, no. 4 (2014): 801-809.
2. Gaskins, Audrey J., Yu-Han Chiu, Paige L. Williams, et al. “Association Between Serum Folate and Vitamin B-12 and Outcomes of Assisted Reproductive Technologies.” American Journal of Clinical Nutrition 102, no. 4 (2015): 943-950.
3. Cueto, Helena T., Anders H. Riis, Elizabeth E. Hatch, et al. “Folic Acid Supplementation and Fecundability: A Danish Prospective Cohort Study.” European Journal of Clinical Nutrition 70, no. 1 (2016): 66-71.

Scroll to Top