Genetics 2017-03-07T13:12:26+00:00

Genetics

Krishna IVF Clinic is a multilingual, state-of-the-art IVF Lab and Fertility Clinic that offers personalised care with latest technology needed to manage infertility & reproductive disorders.

About Genetic lab : For over a decade, Krishna IVF has been providing panoptic genetic diagnostics to our patients. Our genetic laboratory consists of two branches.

  1. cytogenetics
  2. Molecular genetics.

We offer wide range of diagnostics tests like
1. Karyotyping
2. FISH
3. Sperm aneuploidy
4. a) PCR based tests; b) Tuberculosis; c) Cytomegalovirus; d) Hepatitis B virus; e) Human imununodeficiency virus; f) FSHR; g) LHR; h) AnnexinA5; i) Aurorakinase-C; j) Aurorakinase-B; k) HBB; l) CFTR
5. DNA sequence analysis (SNP, Mutation analysis)
6. Aneuploidy screening (13,15,21,X & Y)

Beta Thalassaemia: 

Beta thalassemia is a genetic disorder resulting in the defective production of hemoglobin, caused by mutations in the beta globin gene. There are approximately 200 mutations found to be responsible for causing beta thalassemia. Individuals heterozygous for the mutation has only one copy of mutant gene and other copy with a normal gene and are referred as thalassemia minor. Individuals homozygous for the mutation has mutation in the two genes and no normal gene, and are referred as thalassemia major. ARMS PCR or gene sequencing is performed to detect the type of mutation and as well as to detect whether, the patient is thalassemia minor or major.

Sickle cell disease:

Sickle cell anemia is caused by a point mutation in the beta globin chain of haemoglobin, which distorts red blood cells into a sickle shape. Individuals heterozygous for the mutation has only one copy of mutant gene and other copy with a normal gene and are referred as sickle cell trait. Individuals  homozygous for the mutation has mutation in the two genes and no normal gene, and are referred to as sickle cell disease. ARMS PCR is performed to detect the  mutation and as well as to detect whether, the patient is sickle cell trait or disease.      

Cystic fibrosis: 

Cystic Fibrosis is a genetic disorder that affects mostly lungs, pancreas, liver,kidney and intestine. CFTR mutation testing can be used as an aid in newborn screening, cystic fibrosis diagnosis and reproductive disabilities. More than 2,000 mutations in the CFTR gene have found. Most of the mutations are not associated with cystic fibrosis, but may cause CFTR related disorders. These genetic variants exhibit high level of heterogeneity and vary between different ethnic groups. This test was designed to identify the CFTR mutation present in the protein coding region of the CFTR gene. The test result reduces but do not eliminate the risk of carrying a genetic variation that cause cystic fibrosis/CFTR related disorders.

Dr. T. Sivanarayana
Geneticist

Mr. Ch.Ravi krishna
Geneticist

tejaswiram krishna ivf

Mr. T. Tejaswiram
Geneticist